Doctors Anticipate Successful Tests

By JOSEPH BROWNSTEIN
ABC News Medical Unit
Aug. 20, 2009

With adult trials already under way without serious incident, researchers began giving H1N1 swine flu vaccine to children Wednesday to test the safety and effectiveness for the upcoming flu season.

The trials among children, which will ultimately be conducted at five universities in the United States, will allow researchers to determine effective and safe dosing of the vaccine, which has been designed to prevent a strain of influenza that has already claimed more than 1,000 lives worldwide.

“There was a lot of thought and consideration about the safest but most expeditious way to proceed, and we have completed enrollment,” said Dr. Karen Kotloff, lead investigator of H1N1 studies conducted at the University of Maryland School of Medicine, which is leading the trials. “This is a vaccine that is made in exactly the same way as the standard, licensed flu vaccine.”

Children will receive two doses of vaccine, with half receiving 15 micrograms of antigens — just as they would for each of the three strains in seasonal flu vaccine — while others will receive30 micrograms to see if a higher dose is needed to protect against swine flu.

Younger children will undergo three blood draws to test vaccine effectiveness while children above the age of 10 will undergo five — similar to adults — a concession to the younger children’s dislike of having blood taken.

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